منابع مشابه
Opioids and central sensitisation: I. Preemptive analgesia.
Opioids are powerful analgesics when used to treat acute pain and some forms of chronic pain. A large body of literature has shown that opioids can, in addition, also prevent (this review) or induce and perhaps reverse, some forms central sensitisation in in vitro and in vivo animal models of pain. However, the concept of central sensitisation is, at present, ambiguous and the usefulness of opi...
متن کاملPhysiochemical property of opioids and spinal analgesia
It has been more than two decades since neuraxial opioids first underwent rigorous clinical study for use in humans. The intraspinal route of administration is now commonly used to administer anesthetics and analgesics. Addition of opioids to intraspinal administered local anesthetic provides an effective and prolonged analgesia. However, the physiochemical properties of opioids may influence t...
متن کاملOpioids: from analgesia to anti-hyperalgesia?
Nowadays, opioids are well recognized as unsurpassed analgesics for relieving severe acute and chronic pain. However, as previously suggested (Scholz and Woolf, 2002), clinical pain is not a monolithic entity limited to integration of nociceptive inputs but is associated with neuronal plasticity that by increasing pain elicits pain hypersensitivity might lead to pain pathogenesis. In other word...
متن کاملOpioids inhibit febrile responses in humans, whereas epidural analgesia does not: an explanation for hyperthermia during epidural analgesia.
BACKGROUND Epidural analgesia is frequently associated with hyperthermia during labor and in the postoperative period. The conventional assumption is that hyperthermia is caused by the technique, although no convincing mechanism has been proposed. However, pain in the "control" patients is inevitably treated with opioids, which themselves attenuate fever. Fever associated with infection or tiss...
متن کاملEfficacy of postoperative patient-controlled and continuous infusion epidural analgesia versus intravenous patient-controlled analgesia with opioids: a meta-analysis.
The authors performed a meta-analysis and found that epidural analgesia overall provided superior postoperative analgesia compared with intravenous patient-controlled analgesia. For all types of surgery and pain assessments, all forms of epidural analgesia (both continuous epidural infusion and patient-controlled epidural analgesia) provided significantly superior postoperative analgesia compar...
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ژورنال
عنوان ژورنال: Nature
سال: 2019
ISSN: 0028-0836,1476-4687
DOI: 10.1038/d41586-019-02683-5